Protein Details: Potassium voltage-gated channel protein Shab

Protein ID

ICDB_Pro_0369

Protein Name

Potassium voltage-gated channel protein Shab

Gene Name

Shab; CG43128

Organism

Drosophila melanogaster (Fruit fly)

Length

985 amino acids

AlphaFoldDB

AF-P17970-F1-model_v4.pdb

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Sequence

MVGQLQGGQAAGQQQQQQQATQQQQHSKQQQQQQQQQQQQLQLKQHQQQQQDILYQQHNEAIAIARGLQAATPADIGDNQPYYDTSGNVDWERAMGAGGAGAYGGIGIGSLPAAGGAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKFSEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRVLKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPEAFWWAGITMTTVGYGDICPTTALGKVIGTVCCICGVLVVALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQRMDNLEQDVPVEFECCFCTTKGLPGCHGECIPLRANSV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in late embryos and pupae.

DOI ID

10.1126/science.2493160; 10.1126/science.2333511; 10.1093/nar/18.8.2173; 10.1074/jbc.274.31.22109; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083

RefSeq

NP_523894.2; NP_728783.1

Feature